Effect of Intravenous Aminophylline on Recovery Acceleration from General Anesthesia in Laparotomy Patients: A Bispectral Index Evaluation

Abstract

Background: Postoperative recovery is a critical aspect of surgical care, particularly following general anesthesia. This study explores the impact of intravenous aminophylline on accelerating recovery in laparotomy patients, utilizing the Bispectral Index (BIS) for precise monitoring. Methods: This study was designed as a randomized, double-blind, controlled trial conducted between June and September 2018. The population included patients scheduled for elective laparotomy under general anesthesia with isoflurane inhalation. A total of 46 participants were randomly assigned to one of two groups: the intervention group, which received intravenous aminophylline, and the control group, which received 0.9% NaCl as a placebo. Recovery time was measured from the point of drug administration (T0) using the Bispectral Index (BIS). Statistical analysis included Fisher's exact test to assess normality and the Mann-Whitney test to determine differences between the groups. Results: The research involved 46 participants, evenly distributed into two cohorts. In the aminophylline cohort, the average time to recover was 10.48 minutes, whilst in the NaCl cohort, it was 15.48 minutes. A notable statistical difference was detected between the two cohorts (p < 0.05). Aminophylline demonstrated a significant ability to accelerate recovery time in comparison to NaCl, effectively shortening the recovery period by roughly 50%. Conclusion: Intravenous aminophylline significantly accelerated recovery from general anesthesia in laparotomy patients, as assessed by the Bispectral Index. Its superior efficacy compared to 0.9% NaCl highlights its potential as a valuable intervention in postoperative care.